Medications · GLP-1
Mounjaro Before Surgery
Mounjaro (tirzepatide) works on the GLP-1 and GIP pathways. For surgery, the concern is the same as Ozempic and Wegovy — a slower-emptying stomach.
Quick answer
Why it matters
Like other GLP-1 medicines, Mounjaro delays stomach emptying, so food can stay in the stomach longer than expected — raising aspiration risk under anesthesia.
Recent multi-society guidance moved away from a blanket 'stop it' rule toward identifying higher-risk patients (ongoing nausea, dose-increase phase) and managing them individually.
Do not stop without instruction
What to ask your doctor
- Should I take my usual Mounjaro dose before surgery, or hold it?
- Should I follow a clear-liquid diet for 24 hours beforehand?
- Do my symptoms make me higher risk?
- Anything different because it's a weekly injection?
Red flags — call your team
Red flags — call your team
- Ongoing nausea, vomiting, or bloating
- You recently increased your dose
- You also take it for diabetes (needs a sugar plan)
References
- American Society of Anesthesiologists (ASA) & multi-society consensus on GLP-1 receptor agonists before anesthesia. asahq.org
Frequently asked questions
Do I stop Mounjaro before surgery?
Not necessarily. Many patients can continue GLP-1/GIP medicines before elective surgery; higher-risk patients may follow a 24-hour clear-liquid diet or hold the dose. Tell your team and follow their advice.