Medications · GLP-1
Zepbound Before Surgery
Zepbound is tirzepatide (the same molecule as Mounjaro) prescribed for weight loss. For surgery, the concern is the same as Ozempic and Wegovy: a slower-emptying stomach.
Quick answer
Why it matters
Like other GLP-1 medicines, Zepbound delays stomach emptying, so food can stay in the stomach longer than expected: raising aspiration risk under anesthesia.
Recent multi-society guidance moved away from a blanket 'stop it' rule toward identifying higher-risk patients (ongoing nausea, dose-increase phase) and managing them individually.
Because Zepbound is taken for weight loss, some patients skip mentioning it at the pre-op check: don't. It changes how your anesthesia team plans your day.
Do not stop without instruction
What to ask your doctor
- Should I take my usual Zepbound dose before surgery, or hold it?
- Should I follow a clear-liquid diet for 24 hours beforehand?
- Do my symptoms make me higher risk?
- Anything different because it's a weekly injection?
Red flags, call your team
Red flags, call your team
- Ongoing nausea, vomiting, or bloating
- You recently increased your dose
- You lost weight rapidly in recent weeks (mention it, it can change drug dosing)
References
- American Society of Anesthesiologists (ASA) & multi-society consensus on GLP-1 receptor agonists before anesthesia. asahq.org
Frequently asked questions
Do I stop Zepbound before surgery?
Not necessarily. Many patients can continue GLP-1/GIP medicines before elective surgery; higher-risk patients may follow a 24-hour clear-liquid diet or hold the dose. Tell your team and follow their advice.
Is Zepbound the same as Mounjaro for surgery purposes?
Yes, both are tirzepatide. The surgical guidance is identical; only the licensed use differs (Zepbound for weight loss, Mounjaro for type 2 diabetes).